20
3
Cat. No. | Product Name | Target | Signaling Pathways |
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T4540 |
ML-18
|
Bombesin Receptor | GPCR/G Protein |
ML-18是一种非肽铃蟾肽受体亚型-3 拮抗剂,能够抑制肺癌生长。 | |||
T2126 | MK-5046 | Bombesin Receptor | GPCR/G Protein |
MK5046是一种新型 BRS-3激动剂,同BRS-3结合 (鼠 Ki = 1.6 nM, 人 Ki = 25 nM)的亲和力高。 | |||
TP1701 |
RC-3095 TFA
RC-3095 (TFA) |
Bombesin Receptor | GPCR/G Protein |
RC-3095 TFA (RC-3095(TFA)) 是蛙皮素/胃泌素释放肽受体选择性拮抗剂。它能降低关节炎小鼠的胃氧化损伤,从而发挥保护作用。 | |||
TP1913L1 |
BA 1 acetate(183241-31-8 free base)
|
Bombesin Receptor | GPCR/G Protein |
BA 1 acetate(183241-31-8 free base) 是一种有效的铃蟾肽受体激动剂(BB1、BB2 和 BB3 的 IC50 值分别为 0.26、1.55 和 2.52 nM)。它增强肥胖和糖尿病原发性肌细胞中的葡萄糖转运,还可在体外刺激 NCI-H1299 肺癌细胞增殖。 | |||
TP1931L1 |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base) |
cholecystokinin | GPCR/G Protein |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM);减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。 | |||
T33439 |
MK-7725
MK7725 |
||
Mk-7725 is an effective selective bombesin receptor subtype 3 agonist for the treatment of obesity. | |||
TP2239 |
[D-Phe12]-Bombesin
|
Others | Others |
Bombesin receptor antagonist | |||
T20413 |
Spantide I
Spantide |
||
Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist. | |||
T25522 |
Ici 216140
m216140,Ici216140,m 216140,Ici-216140,m-216140 |
||
ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro). At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rat | |||
TP1916 |
[D-Phe12,Leu14]-Bombesin
|
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Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo. | |||
T71596 |
Bag-2
|
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Bag-2 is a Novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist. | |||
T71595 |
Bag-1
|
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Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist. | |||
T75945 |
BA 1 TFA
|
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BA 1 TFA是一种bombesin (BB)受体家族的激动剂,与Bombesin受体亚型3 (BRS3)、胃泌素释放肽受体 (GRPR)以及神经调节素B受体 (NMBR)具有高度亲和力,其IC50值分别为6、0.4、2.5 nM。 | |||
TP1931 |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
|
||
Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In | |||
T35669 |
Neuromedin C (trifluoroacetate salt)
|
||
Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulatio... | |||
TP2153 |
RC-3095 acetate
|
Others | Others |
RC-3095 acetate is an antagonist of bombesin/gastrin-releasing peptide receptor (GRPR). It exerts protective effects by reducing gastric oxidative injury in the arthritic mice. | |||
T83490 |
[Lys3]-Bombesin
|
||
[Lys3]-Bombesin 是具有生物活性的肽类化合物,用于 PET(正电子发射断层扫描)成像检测 GRPR(胃泌素释放肽受体)阳性的前列腺癌。此外,[Lys3]-Bombesin 及其单克隆抗体的免疫缀合物能特异性诱导 CD64 依赖的单核细胞和中性粒细胞介导的小细胞肺癌细胞裂解。 | |||
T75707 |
BIM-26226
|
||
BIM-26226 是一种胃泌素释放肽,是一种强效选择性的bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放,IC50值在纳摩尔范围内。BIM-26226 可用于癌症研究。 | |||
TP1913 |
BA 1
|
||
Potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro. | |||
TP2026 |
GRP (porcine)
|
||
Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1849 |
Kuwanon H
|
GPR; Bombesin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Kuwanon H 是分离自桑白皮的黄酮类化合物,具有拮抗非肽类蛙皮素受体的活性。Kuwanon H 特异性抑制细胞内胃泌激素释放肽 CRP 与GRP-preferring 受体的结合,Ki 为 290 nM。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
T20604L |
Litorin acetate(55749-97-8 Free base)
|
Bombesin Receptor | GPCR/G Protein |
Litorin acetate 是一种两栖类铃蟾肽衍生物,是一种铃蟾肽受体激动剂。它刺激平滑肌收缩,刺激胃泌素、胃酸和胰腺分泌,抑制体内营养。 |